Introduction. The article deals with the content of theories of «Triple Helix», developed by Western scholars at the beginning of the XXI century, the essence of which is the need for innovative interaction of three driving forces of the modern economy – the university community, industry and the public authorities, and analyzes the practical aspects of this interaction in the Saratov region, shows the advantages and disadvantages of the relationship between data elements. Theoretical analysis. Consideration of the interaction between the elements of the «Triple Helix» involves the use of methods of scientific research. These methods include systemic, complex, statistical methods, analysis and synthesis of the object, the use of special methods of research (interview data). Empirical analysis. In an innovative collaboration at the regional level, considering the possibility of capitalization available cash of material and financial resources of the region and it is shown that in the Saratov region to implement such a capitalization problematic due to the high credit debt in the region. Results. In conclusion, it is concluded that much of the functioning of the «Triple Helix» depends on the activities of the regional public authorities, which must implement appropriate economic policies to increase the capitalization of the available material and educational resources in the Saratov region, to prevent the «brain drain» from the region, to create favorable conditions for the implementation of innovations most gifted students, the scientific community and innovative businesses.