Introduction. This study is devoted to the analysis of industrial policy project instruments implemented by the Russian Industrial Development Fund, from the standpoint of assessing their impact on the systemic results of the industrial development of Russian regions. Theoretical analysis. The industrial sector of the economy has historically played a key role in the socio-economic development of Russia. Given the backbone role of industry in the country’s economy, the issues of state support for industrial development are traditionally the most important on the agenda of the state’s economic policy. Established in 2014, over the past period, the Fund has demonstrated the fl exibility and adaptability of its programs to changing conditions, has provided its customers with convenient tools for concessional lending for technological modernization projects, and, in general, has become the most popular instrument of industrial policy. At the same time, the question of the strategic eff ectiveness of the Fund’s activities as a systemic institution of industrial policy, solving not only local tasks of supporting modernization projects and creating new industries, but also the tasks of industrial development and growth in general, remains open. Empirical analysis. Given that the problem of industrial development is ultimately localized at the level of the constituent entities of the Russian Federation, in this study, based on the methods of regression analysis, an assessment has been made of the impact of the Fund’s activities on the development of the manufacturing sector in the regions of Russia. The work has assessed the impact of projects implemented within the framework of the Fund’s programs on the indicators of the production index and the volume of shipment of goods, services on their own in the manufacturing industry of the region by groups of constituent entities of the Russian Federation, depending on the level of the average annual cost of investment projects implemented with the participation of the Industrial Development Fund. Results.The analysis has showed that the Fund’s current tools have a positive eff ect on the systemic growth and development of industry only up to a certain level of intensity of their use in regions with an average and low level of industrial development. As for industrialized regions, the results obtained here from the standpoint of systemic eff ects of accelerated industrial development are not obvious.