The globalization of the economy, intense competition in the markets, the complexity of patterns of interaction between market actors, accelerating scientific and technological progress, the desire to maximize sales suggests that the main purpose of management is now wrestling with uncertainty, risk minimization, and requires businesses to optimize all business processes. Theoretical analysis. Optimization approach in constructing a system for managing business processes of an enterprise should be expanded logistics approach, which would reduce the overall cost of their organization, enhance the sustainability and competitiveness of the company and to ensure the maximum possible gain in time. The author shows that the establishment and operation of those systems require cooperation and coordination of all the system elements with account taken of the influence of operating factors and variable parameters. Results. The result of applying the integrated simulation system built on the principles of logistics is to build an effective system of management capabilities, development and performance of the whole enterprise. The model of the logistics system submitted by the author shows interrelations between its components and subsystems and helps to adapt to changing external conditions with the use of mathematical tools.