Introduction. The article discusses the experience of foreign countries in the formation and development of innovative systems at the regional level, as well as the possibility of using it in the Russian economy. Goals and objectives. Development of regional innovation system is considered as an important task and a mandatory part of the financial and political activities of federal and regional authorities. The main reason of establishing a regional innovative system is to unite the efforts of municipal authorities, scientific and technical organizations, the education sector and the business section of the economy in the interests of rapid application of science and technology in order to implement the strategic directions of the formation of a certain territory (region) and the reaching the path of innovative lifting by the economy. Empirical analysis. Analyzes the experience of several foreign countries in the formation of regional innovation systems, taking into account the economic characteristics of the countries in question. Scientific parks, incubators, and other similar structures are the necessary part of innovation system in the developed countries of the world. Conclusions. For innovative improvement of regions in Russia we need to ensure conditions for the development of progressive technological structure and the attractiveness of innovative space of regions by forming innovative infrastructure; expansion of staffing system of innovation; involvement in the economic and civil turnover of intellectual property and results of intellectual development.