Introduction. Currently, any activity subject to the destabilizing effect of environmental factors, which reduces the competitiveness, efficiency of business processes and thus achieve planned results of the corresponding goal. Solving this problem requires a search for new tools, methods, process control mechanisms achievement using logistics-oriented concepts that produce a variety of reasons: the need to optimize the management of flows of resources, minimizing costs and risks, improve efficiency and adaptability of activities to environmental change. Theoretical analysis. To obtain the most effective results of operations of the logistics system due to multi- dimensional, multi-dimensionality and complexity of the process control system goals, you need to develop a mechanism for managing this process with the application of the concept of node interference in managing the flow of resources, which is to control actions on the nodes of intersection of the main resource flows drugs to achieve maximum economic benefit from the economic activity and the release of logistical capacity. Results. The result of applying the concept of nodal impacts is optimizing the time and cost of managing flows of resources, risk production and business activities, the maximum adaptation logistics system to environmental changes. Authors’ model of process control mechanism to achieve the goals of drugs based on the concept of nodal actions will achieve the maximum degree of realization of the set goals, improving the competitiveness and efficiency of the overall system by optimizing the process of finding the resources to achieve the goals of the system.