Introduction. The relevance of the topic under consideration, on the one hand, is due to external factors, when decisions of a strictly political nature by the Western world leaders and subsequent economic sanctions “cut Russia off ” from a number of important technologies. On the other hand, the lack of a coherent domestic economic policy leads to a mismatch of targets at the national and regional levels. subjects of economic activity, both at the micro and macro levels. In this regard, the development of methodological foundations that allow for the integration of economic entities at the macro level, while qualitatively improving the efficiency of management is extremely important. Theoretical analysis. The article analyzes and evaluates the international experience of technological development management. The main directions of improving management efficiency have been identified. A structural analysis of the subjects of regional management was carried out, which allowed us to identify the main problems. Results. The necessity of using a project approach based on regional technology platforms is substantiated. An organizational model of regional management is presented, which allows for dynamic technological development in strict compliance with all principles of sustainability. Conclusion. Qualitative improvement of management efficiency is possible only on the basis of integration of both different types of management and target indicators of management entities. Such integration should be based on a new industrial policy and represent a permanent process.